INTESTINAL PERFORATION IN A PATIENT WITH PERITONEAL CARCINOMATOSIS FROM COLON CANCER TREATED WITH REGORAFENIB. DESCRIPTION OF A CASE AND REVIEW OF THE LITERATURE

Regorafenib is a multikinase inhibitor approved for treatment of patients with metastatic Colo-Rectal Cancer (mCRC) and Gastro-Intestinal Stromal Tumor (GIST) progression after the administration of other tyrosine-kinase inhibitors such as imatinib and sunitinib.Only a handful of severe side effects such as intestinal perforations and fistulas have

Background and purpose: Internal mammary lymph node irradiation (IMNI) improves survival in patients with internal BATH SALT REVIVAL mammary lymph node (IMLN) high-risk metastatic breast cancer.The purpose of this study was to study the advantages of internal mammary sentinel lymph node (IMLN) biopsy (IM-SLNB) for assessing prognosis and directing

Proton pump inhibitors (PPIs) are recommended for the prevention of gastrointestinal bleeding in acute coronary syndrome (ACS) patients who receive dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) but have been associated with Vacuum Trim Cover an increased risk of major adverse cardiovascular events (MACE) in these p

A novel grating coupling scheme with simultaneously broadband and wide-angle efficiency for unidirectionally coupling freely propagating light into a silicon waveguide is proposed and theoretically investigated.The coupling structure is composed of two cascaded subgratings with proper spectral and angular intervals.A semi-analytical theory based on

The clavicle, characterized by its S-shaped structure, Motor Parts is anatomically divided into 3 sections: proximal, midshaft, and distal.Clavicle fractures are very common, particularly among children and young adults, especially with certain activities, including mountain biking, skiing, and snowboarding.Approximately 80% of these fractures are